7MbAbstractThe initial aim of the work described in this Thesis was to investigate the lymphoid organ distribution, phenotype and function of the lymphocyte population identified by candidate anti Xenopus natural killer (NK) cell monoclonal antibodies (mAb’s). Since removal of the thymus gland early in larval life (thymectomy) results in the eradication of T cells and subsequent increase in the proportion of candidate NK cells, thymectomised (Tx) Xenopus were integral in the study of this subset of lymphocytes. Phenotypic and functional studies respectively demonstrated that mAb defined candidate NK cells do not belong to the B or T cell lineage and display cytotoxic activity towards MHC class Ia deficient tumour target cells, strengthening the contention that these cells represent the NK subset in Xenopus.
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